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Associate Scientist/Senior Associate Scientist
Molecular Biology

Associate Scientist / Senior Associate Scientist

Molecular Biology

London

£30,000 - £34,000 / £35,000 - £39,000

Why Bastion Therapeutics?

Bastion Therapeutics is a preclinical stage biotechnology company with a mission to develop novel Treg therapies to address the unmet clinical need for inflammatory disorders. We leverage our proprietary platform technology to enhance Tregs to modulate the immune system and overcome challenges associated with existing Treg therapies. Our vision is to provide life-changing therapies that are efficacious, durable and safe to patients suffering from inflammatory disorders.

What are we looking for?

Bastion Therapeutics is seeking a hard-working and resilient Associate Scientist or Senior Associate Scientist to join our Molecular Biology team. The successful candidate will be part of setting up and building out our lab capabilities and will be involved in further developing our GRIT™ cell therapies. In addition, they will investigate Treg immunological processes through ex vivo and in vitro studies. They should have experience with standard cell culture and immunology techniques. The successful candidate is expected to help develop databases and SOPs, carry out independent scientific studies to generate high quality data to inform the development of the GRIT™ platform, and demonstrate critical thinking. 

At Bastion Therapeutics you will be involved in:

  • Establishing and maintaining cell cultures

  • Setting up co-culture assays with immune cells and various other cell types

  • Investigating the phenotypes and functional statuses of immune and non-immune cells

  • Determining cytokine profiles in co-culture models

  • Supporting the design, execution, and development of novel CAR technology and complex research studies

  • Providing support for assay setup, protocol optimisation and troubleshooting

  • Preparing data in a timely manner and presenting findings at team meetings

  • Maintaining highly organised and detailed documentation of experimental procedures

  • Collaborating with other teams to meet deadlines and goals

  • Staying up-to-date with literature and new technologies within the cell therapy field

What you will need to bring to the role - Essential Skills and Experience

  • Desire and ability to work in a fast-paced and dynamic lab-based environment

  • Solid knowledge of molecular biology and CAR technology

  • Good understanding of CAR design and genetic engineering techniques

  • Demonstrated proficiency with immunological assays

  • Familiarity with data analysis softwares such as Graphpad Prism and FlowJo

  • Excellent organisational and record keeping skills

  • Associate Scientist: BSc Molecular Biology or related subject or;

  • Senior Associate Scientist: MRes/MSc Molecular Biology or related subject with 1 year of relevant laboratory experience or BSc Molecular Biology or related subject with 2 years of relevant laboratory experience

What we hope that you can bring to the role - Desired Skills and Experience

  • Previous industry experience

  • Advanced knowledge of molecular biology and CAR technology

  • Extensive experience with CAR design and genetic engineering techniques

  • Good knowledge of T-cell biology and/or Treg biology

  • Demonstrated proficiency with flow cytometry (instrument setup and QC, tissue processing and cell isolation, cell staining for surface markers, cytokines, and transcription factors, acquisition and data handling, multiparameter analysis etc.)

  • Demonstrated proficiency with cytokine analysis (flow cytometry, ELISA, ELISPOT, Multiplex assays)

  • Strong ability with data analysis softwares such as Graphpad Prism and FlowJo

  • Experience with mouse models of autoimmunity and inflammation

  • Previous experience using electronic lab notebooks

Strictly no agencies. Please note that Bastion Therapeutics does not accept applications from recruitment agencies.

Image by Noah Buscher

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Molecular Biology

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Thank you for your interest!

We are addressing the root cause of the disease by restoring balance to a dysregulated immune system

Balancing stones
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