Inflammatory disorders are a group of conditions in which the immune system mistakenly attacks the body's own tissues, leading to inflammation and tissue damage
Inflammatory disorders refer to a group of conditions where the body's immune system triggers an excessive and prolonged inflammatory response. This can lead to tissue damage and dysfunction in affected organs.
Examples include Neuroinflammatory disorders (e.g. amytrophic lateral sclerosis and multiple sclerosis) and Peripheral inflammatory disorders (e.g. systemic lupus erythematosus and inflammatory bowel disease).
Inflammatory Disorders have a significant global prevalence and incidence. The exact numbers vary depending on the specific disorder, but collectively, they affect millions of people worldwide and are increasing every year.
Patients face considerable systemic medical challenges and often experience comorbidities, i.e. additional health conditions alongside their primary disorder. These comorbidities can further complicate the management and prognosis of the primary inflammatory disorder.
Gold standard therapies uses blunt-force strategies to beat a dysregulated immune system into submission and include e.g. nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and biologic agents.
One of the challenges associated with the use of these therapies is that they are not effective for the majority of patients and may cause significant side effects. In addition, long-term use of these medications may lead to the development of drug resistance, reduced efficacy, and other serious complications such as infection and cancer.